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Silencing of MDR 1 gene in cancer cells by siRNA.
Logashenko, E B; Vladimirova, A V; Repkova, M N; Venyaminova, A G; Chernolovskaya, E L; Vlassov, V V.
Affiliation
  • Logashenko EB; Institute of Chemical Biology and Fundamental Medicine, Novosibirsk, Russia. evg_log@niboch.nsc.ru
Nucleosides Nucleotides Nucleic Acids ; 23(6-7): 861-6, 2004 Oct.
Article in En | MEDLINE | ID: mdl-15560073
ABSTRACT
Inhibition of p-glycoprotein (PGP) expression and reverse of multidrug resistance (MDR) phenotype in KB-8-5 cells by synthetic 21-bp double-stranded oligoribonucleotides were investigated. siRNA constructs for the efficient down regulation of MDR1 that are active in nanomolar concentrations and cause reversal of MDR phenotype in cells were developed.
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Collection: 01-internacional Database: MEDLINE Main subject: Genes, MDR / Gene Silencing / RNA, Small Interfering Limits: Humans Language: En Journal: Nucleosides Nucleotides Nucleic Acids Journal subject: BIOQUIMICA Year: 2004 Document type: Article Affiliation country: Rusia
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PubMed Links

Collection: 01-internacional Database: MEDLINE Main subject: Genes, MDR / Gene Silencing / RNA, Small Interfering Limits: Humans Language: En Journal: Nucleosides Nucleotides Nucleic Acids Journal subject: BIOQUIMICA Year: 2004 Document type: Article Affiliation country: Rusia