Liver transplantation for acute hepatic failure.
Transplant Proc
; 36(8): 2226-7, 2004 Oct.
Article
in En
| MEDLINE
| ID: mdl-15561199
ABSTRACT
INTRODUCTION:
The mortality rate of acute hepatic failure (AHF) with conservative treatment is 40% to 90%, depending on the etiology. Hepatitis B infection is the major cause of AHF in Asia. In this study, we examined the role of liver transplantation for adult patients with AHF.METHODS:
Sixteen patients with AHF received liver transplants in the past 6 years. Eight patients received cadaveric donor and another 8 living-related donor grafts. Fifteen patients suffered from hepatitis B-related disease and 1 had drug-induced AHF. Extracorporeal charcoal hemoperfusion was used as a bridge to liver transplantation in the first 2 patients and plasma exchange was used in the following patients.RESULTS:
One patient died 1 month after the operation due to primary nonfunction. The other 15 patients are alive with good graft function at 2 months to 6 years follow-up. The success rate is 94%. Postoperative complications included infection in 10 patients (62.5%), acute rejection in 4 patients (25%), and biliary complication in 2 patients (12.5%). No neurological complications were noted.CONCLUSION:
Liver transplantation is the most effective treatment for patients with AHF. Living donors may be considered due to the organ shortage and the critical patient disease.
Search on Google
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Liver Transplantation
/
Liver Failure, Acute
Type of study:
Observational_studies
/
Risk_factors_studies
Limits:
Humans
Language:
En
Journal:
Transplant Proc
Year:
2004
Document type:
Article
Affiliation country:
Taiwán