Synthesis of a library of benzoindolizines using poly(ethylene glycol) as soluble support.
Bioorg Med Chem Lett
; 15(2): 453-8, 2005 Jan 17.
Article
in En
| MEDLINE
| ID: mdl-15603972
ABSTRACT
A library of benzoindolizines (pyrrolo [1,5-a] quinolines 10 and pyrrolo [1,5-a] quinolines 9) has been synthesized using poly(ethylene glycol) (PEG) as soluble polymer support. The PEG-supported isoquinolinium salt 4 reacted, respectively, with active alkenes 11 using tetrakispyridinecobalt(II) dichromate (TPCD) as oxidant or alkynes 12 to give 10, of which yields were from moderate to high. By analogy, the reaction of PEG-supported quinolinium salt 3 with 12 was to produce 9. However, in the presence of TPCD the reaction of 3 with 11 afforded indolizines 8, which was discovered firstly.
Search on Google
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Polyethylene Glycols
/
Benzene
Language:
En
Journal:
Bioorg Med Chem Lett
Journal subject:
BIOQUIMICA
/
QUIMICA
Year:
2005
Document type:
Article
Affiliation country:
China