Magnetic resonance imaging detection of an experimental pulmonary perfusion deficit using a macromolecular contrast agent. Polylysine-gadolinium-DTPA40.
Invest Radiol
; 27(5): 346-51, 1992 May.
Article
in En
| MEDLINE
| ID: mdl-1582816
ABSTRACT
RATIONALE AND OBJECTIVES:
This study was designed to evaluate the potential of a blood-pool magnetic resonance (MR) contrast agent, polylysine-gadolinium-DTPA40 (polylysine-Gd-DTPA40) for detecting pulmonary perfusion defects. MATERIALS ANDMETHODS:
Pulmonary emboli were induced in 10 rats by venous injection of 0.2 mL of air. Axial spin-echo images were acquired (TR = 800 mseconds; TE = 6 mseconds) before and after air injection and serially after the administration of polylysine-Gd-DTPA40. The embolism model was confirmed by scintigraphy using 99mTc-macroaggregated albumin.RESULTS:
Signal intensity differences between normal and embolized lungs before and after the air injection were less than 25%. After polylysine-Gd-DTPA40 administration, signal intensity of the perfused lung increased more than 200%, whereas the embolized lung increased by only 25%. Signal intensities of the perfused lung remained stable for 1 hour, whereas signal intensities of the embolized lung gradually increased for 20 minutes as the air embolus dissolved.CONCLUSION:
Magnetic resonance imaging (MRI) enhanced with a macromolecular blood-pool contrast agent can be used to detect acute pulmonary embolism in a confirmed animal model.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Organometallic Compounds
/
Polylysine
/
Pulmonary Embolism
/
Magnetic Resonance Imaging
/
Contrast Media
/
Gadolinium DTPA
/
Pentetic Acid
/
Embolism, Air
/
Gadolinium
Type of study:
Diagnostic_studies
/
Prognostic_studies
Limits:
Animals
Language:
En
Journal:
Invest Radiol
Year:
1992
Document type:
Article