5-(3-Bromophenyl)-7-(6-morpholin-4-ylpyridin-3-yl)pyrido[2,3-d]pyrimidin-4-ylamine: structure-activity relationships of 7-substituted heteroaryl analogs as non-nucleoside adenosine kinase inhibitors.

Matulenko, Mark A; Lee, Chih-Hung; Jiang, Meiqun; Frey, Robin R; Cowart, Marlon D; Bayburt, Erol K; Didomenico, Stanley; Gfesser, Gregory A; Gomtsyan, Arthur; Zheng, Guo Zhu; McKie, Jeffery A; Stewart, Andrew O; Yu, Haixia; Kohlhaas, Kathy L; Alexander, Karen M; McGaraughty, Steve; Wismer, Carol T; Mikusa, Joseph; Marsh, Kennan C; Snyder, Ronald D; Diehl, Marilyn S; Kowaluk, Elizabeth A; Jarvis, Michael F; Bhagwat, Shripad S

Matulenko, Mark A; Lee, Chih-Hung; Jiang, Meiqun; Frey, Robin R; Cowart, Marlon D; Bayburt, Erol K; Didomenico, Stanley; Gfesser, Gregory A; Gomtsyan, Arthur; Zheng, Guo Zhu; McKie, Jeffery A; Stewart, Andrew O; Yu, Haixia; Kohlhaas, Kathy L; Alexander, Karen M; McGaraughty, Steve; Wismer, Carol T; Mikusa, Joseph; Marsh, Kennan C; Snyder, Ronald D; Diehl, Marilyn S; Kowaluk, Elizabeth A; Jarvis, Michael F; Bhagwat, Shripad S.

Affiliation

Matulenko MA; Neuroscience Research, Global Pharmaceutical Research, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL 60064, USA. mark.a.matulenko@abbott.com

Bioorg Med Chem ; 13(11): 3705-20, 2005 Jun 01.

Article in En | MEDLINE | ID: mdl-15863000

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Collection: 01-internacional Database: MEDLINE Main subject: Pyrimidines / Adenosine Kinase / Morpholines / Enzyme Inhibitors Limits: Animals Language: En Journal: Bioorg Med Chem Journal subject: BIOQUIMICA / QUIMICA Year: 2005 Document type: Article Affiliation country: Estados Unidos Country of publication: Reino Unido

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