[Worsening of subacute lupus erythematosus induced by infliximab]. / Aggravation d'un lupus érythémateux subaigu sous infliximab.
Ann Dermatol Venereol
; 132(4): 349-53, 2005 Apr.
Article
in Fr
| MEDLINE
| ID: mdl-15886563
ABSTRACT
BACKGROUND:
Infliximab (Remicade) is an anti-TNF alpha indicated in the treatment of chronic inflammatory rheumatism, notably rheumatoid arthritis. CASE-REPORT We report the case of a 56 year-old woman who developed severe worsening of an SSA-positive subacute lupus erythematosus on initiation of treatment with infliximab for rheumatoid arthritis.DISCUSSION:
A review of the literature found 30 cases of drug-induced lupus and listed the autoimmune modifications induced by anti-TNF alpha. This first case of subacute lupus erythematosus, existing before the introduction of treatment and worsening during the latter, emphasizes the risk of developing a severe flare of an autoimmune disease during treatment with anti-TNF alpha. It raises the question of the relative contraindications of anti-TNF alpha in patients with lupus erythematosus.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Lupus Erythematosus, Cutaneous
/
Antirheumatic Agents
/
Antibodies, Monoclonal
Limits:
Female
/
Humans
/
Middle aged
Language:
Fr
Journal:
Ann Dermatol Venereol
Year:
2005
Document type:
Article