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Heteroaromatic side-chain analogs of pregabalin.
Schelkun, Robert M; Yuen, Po-wai; Wustrow, David J; Kinsora, Jack; Su, Ti-Zhi; Vartanian, Mark G.
Affiliation
  • Schelkun RM; PGRD Michigan Laboratories, Ann Arbor, MI 48105, USA.
Bioorg Med Chem Lett ; 16(9): 2329-32, 2006 May 01.
Article in En | MEDLINE | ID: mdl-16099652
ABSTRACT
A series of heteroaromatic analogs of pregabalin has been identified that possess anticonvulsant activity in the DBA/2 mouse model. The methods of synthesis and preliminary pharmacology are discussed herein.
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Collection: 01-internacional Database: MEDLINE Main subject: Seizures / Gamma-Aminobutyric Acid / Anticonvulsants Limits: Animals Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2006 Document type: Article Affiliation country: Estados Unidos
Search on Google
Add to My VHL
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PubMed Links

Collection: 01-internacional Database: MEDLINE Main subject: Seizures / Gamma-Aminobutyric Acid / Anticonvulsants Limits: Animals Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2006 Document type: Article Affiliation country: Estados Unidos