Respiratory Tract Diseases; Adrenal Cortex Hormones/pharmacology; Adrenal Cortex Hormones/therapeutic use; Animals; Annexins/pharmacology; Annexins/therapeutic use; Antibodies, Monoclonal/therapeutic use; Asthma/drug therapy; Basiliximab; Controlled Clinical Trials as Topic; Disease Models, Animal; Drug Resistance; Drugs, Investigational/chemistry; Drugs, Investigational/therapeutic use; Histone Deacetylases/metabolism; Humans; Inflammation/drug therapy; Inflammation/etiology; Inflammation/physiopathology; Macrophage Migration-Inhibitory Factors/metabolism; Mice; Pulmonary Disease, Chronic Obstructive/drug therapy; Pulmonary Disease, Chronic Obstructive/etiology; Pulmonary Disease, Chronic Obstructive/physiopathology; Rats; Recombinant Fusion Proteins/therapeutic use; Respiratory Tract Diseases/drug therapy; Respiratory Tract Diseases/etiology; Respiratory Tract Diseases/physiopathology