Effects of probiotics on the severity of experimental acute pancreatitis.
Eur J Clin Nutr
; 60(4): 464-8, 2006 Apr.
Article
in En
| MEDLINE
| ID: mdl-16340953
ABSTRACT
OBJECTIVE:
This study was designed to evaluate the effects of probiotics on the severity of experimental acute pancreatitis.DESIGN:
Experimental study.SETTING:
Experiments were done in a laboratory at Haydarpasa Numune Teaching and Research Hospital.SUBJECTS:
A total of 50 Wistar rats were randomly divided into five groups.INTERVENTIONS:
Group 1 was control group. Group 2 received an intraperitoneal injection of a 20% solution in 0.15 mol/l NaCL. Group 3 was injected NaCL and fed with probiotics. Acute pancreatitis was induced in rats by intrperitoneal injection of L-Arginine in groups 4 and 5. The rats in group 5 were treated with probiotics. The pancreas was removed for histologic examination. Evaluation of the pathologic changes was done by a new combined histopathologic grading scale.RESULTS:
The mean scores of fibrosis, acinar cell loss, oedema, parenchymal necrosis, mononuclear cells infiltration, polymorphonuclear leucocytes infiltration, ductal damage and atypical reactive regeneration in group 5 were significantly lower than group 4.CONCLUSIONS:
We demonstrated that enteral feedings with added probiotics can reduce the severity of acute pancreatitis. SPONSORSHIP None.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Pancreatitis, Acute Necrotizing
/
Probiotics
Limits:
Animals
Language:
En
Journal:
Eur J Clin Nutr
Journal subject:
CIENCIAS DA NUTRICAO
Year:
2006
Document type:
Article
Affiliation country:
Turquía