Lymphocyte volume and conductivity indices of the haematology analyser Coulter GEN.S in lymphoproliferative disorders and viral diseases.
Clin Lab Haematol
; 28(1): 1-8, 2006 Feb.
Article
in En
| MEDLINE
| ID: mdl-16430452
ABSTRACT
The haematology analyser Coulter GEN.S gives a set of data -'positional parameters'- defining white blood cell (WBC) populations by mean of index values (mean and standard deviation of volume, conductivity and scatter, used to identify the WBC populations). The volume and conductivity parameters related to the lymphocytes were analysed at diagnosis in patients suffering from chronic B-lymphocytic leukaemia (B-CLL), other non-CLL lymphoproliferative disorders (OLPD) and viral diseases. The standard deviation of volume index (SDVI) is significantly higher in the three groups, whereas the mean volume index (MVI) is significantly lower in B-CLL, and increased in OLPD and viral diseases. These two groups could be distinguished by their mean conductivity index (MCI), which is significantly lower in viral disease group. Cut-offs were calculated for each parameter by the mean of Receiver Operating Characteristic (ROC) analysis. The study of the detection performances showed that the combination of lymphocyte count with SDVI, MVI and MCI could be used with a good sensitivity and specificity to discriminate between the most frequent lymphocyte pathologies, even in patients with normal lymphocyte count.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Virus Diseases
/
Lymphocytes
/
Lymphoproliferative Disorders
Type of study:
Prognostic_studies
Limits:
Humans
Language:
En
Journal:
Clin Lab Haematol
Year:
2006
Document type:
Article
Affiliation country:
Francia