[Expression of P-gp, GST-pi and Topo II alpha in gastric and colorectal cancers and their clinical significance].
Zhonghua Zhong Liu Za Zhi
; 27(12): 738-40, 2005 Dec.
Article
in Zh
| MEDLINE
| ID: mdl-16483485
ABSTRACT
OBJECTIVE:
To study the expression and clinical significance of P-gp, GST-pi and Topo II alpha in gastric and colorectal cancers.METHODS:
The expression of P-gp, GST-pi and Topo II alpha in 83 cases with gastric or colorectal cancer were examined by immunohistochemistry S-P.RESULTS:
The positive expression rates of P-gp, GST-pi, Topo II alpha in normal tissue and gastric and colorectal cancers were 69.9%, 65.1%, 50.6% and 83.1%, 85.5%, 45.8%, respectively. The positive rates of P-gp and GST-pi in gastric and colorectal cancer were significantly higher than those in normal gastric and colorectal tissue (P < 0.05). The expression of Topo II alpha in poorly differentiated cancers was significantly higher than that in well-and moderately differentiated cancers. There was no correlation between other items and clinicopathological parameters (P > 0.05).CONCLUSION:
P-gp, GST-pi and Topo II alpha play important role in multidrug resistance. Their mechanisms of drug resistance were different. The detection of expression of P-gp, GST-pi and Topo II alpha has an important guiding significance in chemotherapy for gastric and colorectal cancers.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
DNA Topoisomerases, Type II
/
ATP Binding Cassette Transporter, Subfamily B, Member 1
/
Drug Resistance, Neoplasm
/
DNA-Binding Proteins
/
Glutathione S-Transferase pi
/
Gastrointestinal Neoplasms
/
Antigens, Neoplasm
Limits:
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Male
/
Middle aged
Language:
Zh
Journal:
Zhonghua Zhong Liu Za Zhi
Year:
2005
Document type:
Article
Affiliation country:
China