Structure of human factor VIIa/tissue factor in complex with a peptide-mimetic inhibitor: high selectivity against thrombin by introducing two charged groups in P2 and P4.

Kadono, Shojiro; Sakamoto, Akihisa; Kikuchi, Yasufumi; Oh-Eda, Masayoshi; Yabuta, Naohiro; Koga, Takaki; Hattori, Kunihiro; Shiraishi, Takuya; Haramura, Masayuki; Kodama, Hirofumi; Ono, Yoshiyuki; Esaki, Toru; Sato, Haruhiko; Watanabe, Yoshiaki; Itoh, Susumu; Ohta, Masateru; Kozono, Toshiro

Kadono, Shojiro; Sakamoto, Akihisa; Kikuchi, Yasufumi; Oh-Eda, Masayoshi; Yabuta, Naohiro; Koga, Takaki; Hattori, Kunihiro; Shiraishi, Takuya; Haramura, Masayuki; Kodama, Hirofumi; Ono, Yoshiyuki; Esaki, Toru; Sato, Haruhiko; Watanabe, Yoshiaki; Itoh, Susumu; Ohta, Masateru; Kozono, Toshiro.

Affiliation

Kadono S; Fuji Gotemba Research Laboratories, Chugai Pharmaceutical Co. Ltd, 1-135 Komakado, Gotemba, Shizuoka 412-8513, Japan. kadonosuj@chugai-pharm.co.jp

Acta Crystallogr Sect F Struct Biol Cryst Commun ; 61(Pt 2): 169-73, 2005 Feb 01.

Article in En | MEDLINE | ID: mdl-16510984

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Thromboplastin / Factor VIIa / Anticoagulants Type of study: Prognostic_studies Limits: Humans Language: En Journal: Acta Crystallogr Sect F Struct Biol Cryst Commun Year: 2005 Document type: Article Affiliation country: Japón Country of publication: Reino Unido

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