Vasorelaxant activity of phthalazinones and related compounds.
Bioorg Med Chem Lett
; 16(10): 2786-90, 2006 May 15.
Article
in En
| MEDLINE
| ID: mdl-16513345
ABSTRACT
Several series of dihydrostilbenamide, imidazo[2,1-a]isoindole, pyrimido[2,1-a]isoindole and phthalazinone derivatives were obtained and their vasorelaxant activity was measured on isolated rat aorta rings pre-contracted with phenylephrine (10(-5)M). Some phthalazinones attained, practically, the total relaxation of the organ at micromolar concentrations. For the most potent compound 9h (EC(50)=0.43microM) the affinities for alpha(1A), alpha(1B) and alpha(1D) adrenergic sub-receptors were determined.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Phthalazines
/
Vasodilation
Limits:
Animals
Language:
En
Journal:
Bioorg Med Chem Lett
Journal subject:
BIOQUIMICA
/
QUIMICA
Year:
2006
Document type:
Article
Affiliation country:
España