[Duration of action of silodosin (KMD-3213) against phenylephrine-induced increase in intraurethral pressure in rats].
Yakugaku Zasshi
; 126 Spec no.: 231-6, 2006 Mar.
Article
in Ja
| MEDLINE
| ID: mdl-16518088
ABSTRACT
The duration of action of Silodosin (KMD-3213) against the phenylephrine-induced increase in intraurethral pressure in urethane-anesthetized rats was compared with that of tamsulosin hydrochloride. Silodosin, tamsulosin, or vehicle was orally administered to fasted male rats. Then, under urethane anesthesia, a cannula was inserted into the prostatic urethra. Phenylephrine, at a dose of 30 microg/kg, was infused (infusion rate 36 ml/h; infusion time 100 s/kg) via the femoral vein at 12 h, 18 h, or 24 h after administration of the study drug, and the intraurethral pressure in the prostate region was measured. Although the plasma silodosin concentration would have resolved within a few hours, silodosin significantly inhibited the phenylephrine-induced increase in intraurethral pressure (versus the vehicle-treated group) at 12 h, 18 h, and 24 h after its oral administration (at doses of 100 microg/kg and above, 1000 microg/kg and above, and 3000 microg/kg, respectively). On the other hand, tamsulosin hydrochloride showed no inhibitory action at 24 h after its oral administration at doses up to 3000 microg/kg. Thus, silodosin inhibits the phenylephrine-induced increase in intraurethral pressure for a longer time than tamsulosin hydrochloride.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Phenylephrine
/
Pressure
/
Urethra
/
Adrenergic alpha-Antagonists
/
Adrenergic alpha-1 Receptor Antagonists
/
Indoles
Limits:
Animals
Language:
Ja
Journal:
Yakugaku Zasshi
Year:
2006
Document type:
Article
Affiliation country:
Japón
Publication country:
JAPAN
/
JAPON
/
JAPÃO
/
JP