TRAF3: a new regulator of type I interferons.
Cell Cycle
; 5(8): 804-7, 2006 Apr.
Article
in En
| MEDLINE
| ID: mdl-16582590
ABSTRACT
Type I interferons are a major and essential component of the mammalian antiviral response. While many cell types produce type I interferons following viral infection, how cells detect the virus has remained a mystery for many years. Recently, multiple genome-encoded viral recognition receptors have been identified. Interestingly, all of the major viral recognition pathways characterized thus far require TRAF3 to initiate type I interferon production. In this review, we comment on the mechanistic and biological implications for the new role of TRAF3 in innate antiviral immunity.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Virus Diseases
/
Interferon Type I
/
Gene Expression Regulation
/
TNF Receptor-Associated Factor 3
/
Immunity, Innate
Type of study:
Prognostic_studies
Limits:
Animals
/
Humans
Language:
En
Journal:
Cell Cycle
Year:
2006
Document type:
Article
Affiliation country:
Estados Unidos