[Increasing antibiotic resistance in urinary tract infections]. / Økende forekomst av antibiotikaresistens ved urinveisinfeksjoner.
Tidsskr Nor Laegeforen
; 126(8): 1058-60, 2006 Apr 06.
Article
in Nor
| MEDLINE
| ID: mdl-16619066
ABSTRACT
BACKGROUND:
There is increasing focus on the development of bacterial antibiotic resistance. MATERIALS ANDMETHODS:
We conducted a retrospective study of urine samples from patients resident in a Norwegian county, comparing 9121 samples culture-positive in 2003-04 with 28 066 samples in 1997-99. Determination of resistance was done with the MAST automatic multipoint inoculator system.RESULTS:
Escherichia coli was found in 68% and 56% of out-patient and in-patient isolates respectively. Significant declines in mecillinam sensitivity (from 96% to 94%), nitrofurantoin sensitivity (from 97% to 95%) and sulfonamide sensitivity (from 73% to 71%) in in-patient E. coli isolates were found. In out-patients we found significant reductions in sensitivity to ampicillin (from 78% to 76%) and trimethoprim (from 83% to 82%). For urinary tract infection isolates as a whole, the greatest sensitivity was observed for nitrofurantoin 85% in in-patient isolates and 75% in out-patient isolates, but there was a significant decline in resistance to several antibiotics.INTERPRETATION:
Increasing antibiotic resistance may be related to increasing antibiotic use. Mecillinam and nitrofurantoin may be considered first-choice preparations as E. coli is the dominant etiological agent and shows the greatest sensitivity to these two antibiotics.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Urinary Tract Infections
/
Drug Resistance, Bacterial
Type of study:
Observational_studies
Limits:
Humans
Country/Region as subject:
Europa
Language:
Nor
Journal:
Tidsskr Nor Laegeforen
Year:
2006
Document type:
Article