Predictors of good prognosis in total anterior circulation infarction within 6 h after onset under conventional therapy.
Acta Neurol Scand
; 113(5): 301-6, 2006 May.
Article
in En
| MEDLINE
| ID: mdl-16629765
ABSTRACT
OBJECTIVE:
We investigated the predictors of good prognosis in total anterior circulation infarction (TACI), under conventional therapy.METHODS:
We enrolled 166 patients with first-ever ischemic stroke within 6 h after onset with symptoms of TACI. Sixty-three patients (38.0%) with good outcome [G group, the modified Rankin Disability Scale (mRS) after 3 months < or =3] and 103 patients (62.0%) with bad outcome (B group, mRS >3) were compared.RESULTS:
On univariate analysis, G group patients were significantly younger, had lower score in the National Institutes of Health Stroke Scale (NIHSS) of total and consciousness sub-score, had lower rate of clinical deterioration. On cranial CT at entry, three early CT signs [hyperdense middle cerebral artery (MCA) sign, hypodensity of >1/3 MCA and brain swelling] were significantly more frequent in the B group. On the second CT at 24-48 h, infarct area as assessed by the Alberta Stroke Programme Early CT Score (ASPECTS) was significantly smaller in the G group. Multivariate analysis with logistic regression revealed age <7 0 years, NIHSS < or =15, no clinical deterioration, and only no brain swelling in early CT signs, and ASPECTS > or =7 as independent predictors of good prognosis.CONCLUSIONS:
Some clinical variables are useful in predicting outcome in TACI within the early period after stroke onset.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Platelet Aggregation Inhibitors
/
Brain Infarction
/
Fibrinolytic Agents
Type of study:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Aged
/
Aged80
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Acta Neurol Scand
Year:
2006
Document type:
Article
Affiliation country:
Japón