Design of potent, orally available antagonists of the transient receptor potential vanilloid 1. Structure-activity relationships of 2-piperazin-1-yl-1H-benzimidazoles.

Ognyanov, Vassil I; Balan, Chenera; Bannon, Anthony W; Bo, Yunxin; Dominguez, Celia; Fotsch, Christopher; Gore, Vijay K; Klionsky, Lana; Ma, Vu V; Qian, Yi-Xin; Tamir, Rami; Wang, Xianghong; Xi, Ning; Xu, Shimin; Zhu, Dawn; Gavva, Narender R; Treanor, James J S; Norman, Mark H

Ognyanov, Vassil I; Balan, Chenera; Bannon, Anthony W; Bo, Yunxin; Dominguez, Celia; Fotsch, Christopher; Gore, Vijay K; Klionsky, Lana; Ma, Vu V; Qian, Yi-Xin; Tamir, Rami; Wang, Xianghong; Xi, Ning; Xu, Shimin; Zhu, Dawn; Gavva, Narender R; Treanor, James J S; Norman, Mark H.

Affiliation

Ognyanov VI; Department of Chemistry Research and Discovery, Amgen Inc., One Amgen Center Drive, Thousand Oaks, California 91320-1799, USA. vassilo@amgen.com

J Med Chem ; 49(12): 3719-42, 2006 Jun 15.

Article in En | MEDLINE | ID: mdl-16759115

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Collection: 01-internacional Database: MEDLINE Main subject: Piperazines / Benzimidazoles / TRPV Cation Channels / Analgesics Type of study: Prognostic_studies Limits: Animals Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2006 Document type: Article Affiliation country: Estados Unidos Country of publication: Estados Unidos

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