Synthesis and anticancer activity of lavendustin A derivatives containing arylethenylchromone substituents.
Eur J Med Chem
; 41(8): 991-6, 2006 Aug.
Article
in En
| MEDLINE
| ID: mdl-16762460
ABSTRACT
2-Styrylchromones, which are relatively scarce in nature, have been reported to possess potent cytotoxicities on KB cell line. Lavendustin A, a metabolite of Streptomyces griseolavendus, has been shown to inhibit a growth of A431 cell line. Accordingly, a series of compounds 3a-g having structural features of styrylchromones and lavendustin A were synthesized and evaluated for cytotoxicity using SRB assay on four tumor cell lines. Compounds 3a-g were synthesized by the condensation of 2-methylchromone derivative 7 with several aromatic aldehydes. Among synthesized, compound 3e showed the significant cytotoxic activity on HCT-15 cell line with IC(50) values of 7.17 microg/ml indicating that lavendustin A derivatives containing 2-arylethenylchromone ring have a potential in anti-tumor application.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Phenols
/
Chromones
/
Antineoplastic Agents
Limits:
Humans
Language:
En
Journal:
Eur J Med Chem
Year:
2006
Document type:
Article