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A strong glutathione S-transferase inhibitor overcomes the P-glycoprotein-mediated resistance in tumor cells. 6-(7-Nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol (NBDHEX) triggers a caspase-dependent apoptosis in MDR1-expressing leukemia cells.
Turella, Paola; Filomeni, Giuseppe; Dupuis, Maria Luisa; Ciriolo, Maria Rosa; Molinari, Agnese; De Maria, Francesca; Tombesi, Marina; Cianfriglia, Maurizio; Federici, Giorgio; Ricci, Giorgio; Caccuri, Anna Maria.
Affiliation
  • Turella P; Department of Chemical Sciences and Technologies, University of Rome Tor Vergata, 00133 Rome, Italy.
J Biol Chem ; 281(33): 23725-32, 2006 Aug 18.
Article in En | MEDLINE | ID: mdl-16769721
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Collection: 01-internacional Database: MEDLINE Main subject: Oxadiazoles / Piperazines / Leukemia, T-Cell / Apoptosis / ATP Binding Cassette Transporter, Subfamily B, Member 1 / Caspases / Enzyme Inhibitors / Glutathione Transferase Limits: Humans Language: En Journal: J Biol Chem Year: 2006 Document type: Article Affiliation country: Italia
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Collection: 01-internacional Database: MEDLINE Main subject: Oxadiazoles / Piperazines / Leukemia, T-Cell / Apoptosis / ATP Binding Cassette Transporter, Subfamily B, Member 1 / Caspases / Enzyme Inhibitors / Glutathione Transferase Limits: Humans Language: En Journal: J Biol Chem Year: 2006 Document type: Article Affiliation country: Italia