A strong glutathione S-transferase inhibitor overcomes the P-glycoprotein-mediated resistance in tumor cells. 6-(7-Nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol (NBDHEX) triggers a caspase-dependent apoptosis in MDR1-expressing leukemia cells.
J Biol Chem
; 281(33): 23725-32, 2006 Aug 18.
Article
in En
| MEDLINE
| ID: mdl-16769721
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Oxadiazoles
/
Piperazines
/
Leukemia, T-Cell
/
Apoptosis
/
ATP Binding Cassette Transporter, Subfamily B, Member 1
/
Caspases
/
Enzyme Inhibitors
/
Glutathione Transferase
Limits:
Humans
Language:
En
Journal:
J Biol Chem
Year:
2006
Document type:
Article
Affiliation country:
Italia