[Recurrent intraparenchimal haemorrhages in a patient with cerebral amyloidotic angiopathy: description of one autopsy case]. / Emorragie intracerebrali ricorrenti in paziente con angiopatia cerebrale amiloidea: descrizione di un caso autoptico.
Pathologica
; 98(1): 44-7, 2006 Feb.
Article
in It
| MEDLINE
| ID: mdl-16789686
ABSTRACT
Cerebral amyloidotic angiopathy represents the most frequent cause of lobar haematoma in young patients and represents 5-10% of the non-traumatic cerebral haemorrhages. In the present work, we describe one autoptic case of recurrent cerebral haemorrhages in a 58-year-old woman. Macroscopically in the brain multiple haemorragic areas were present in the right frontal pole, right frontal and temporo-parietal lobes with homolateral ventricular inundation. The histological, histochemical, immunohistochemical, ultrastructural and biomolecular investigations confirmed the presence of amyloid deposits in the middle-size and little-size cerebral arteries. We report, moreover, a novel mutation (Leu705Val) within the Abeta sequence of a AbetaPP in a family with autosomal dominant, recurrent intracerebral hemorrhages beginning in the sixth decade of life.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Cerebral Hemorrhage
/
Amyloid beta-Protein Precursor
/
Cerebral Amyloid Angiopathy, Familial
Type of study:
Diagnostic_studies
/
Etiology_studies
Limits:
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Language:
It
Journal:
Pathologica
Year:
2006
Document type:
Article
Affiliation country:
Italia