[Dependence of the carcinogenicity of nitro compounds on their structural characteristics].
Genetika
; 42(5): 611-9, 2006 May.
Article
in Ru
| MEDLINE
| ID: mdl-16808241
ABSTRACT
A new approach to the description of quantitative structure-activity relationships (QSAR analysis) based on compound descriptors has been used. The effect of the structural characteristics of nitric compounds on their carcinogenicity has been studied. It has been found that the carcinogenicity of nitric compounds is determined by the presence of furyl and/or azole heterocycles not condensed with benzene rings in their molecular structures. The carcinogenicity of the nitric compounds in which the benzene ring is the basic structure is determined by the presence of other substituents (halogens, amines, and methyl groups) and their positions relative to the nitro group.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Carcinogens
/
Nitro Compounds
Type of study:
Prognostic_studies
Limits:
Animals
Language:
Ru
Journal:
Genetika
Year:
2006
Document type:
Article