Embryo aneuploidy screening for repeated implantation failure and unexplained recurrent miscarriage.
Reprod Biomed Online
; 13(1): 38-46, 2006 Jul.
Article
in En
| MEDLINE
| ID: mdl-16820107
ABSTRACT
Among other factors, chromosomal abnormalities that originate from gametogenesis and preimplantation embryonic development are thought to be one of the major contributing factors for early embryonic death and failure of pregnancy. However, so far, no non-invasive technique exists that allows the detection of the chromosomal complement of an oocyte or a developing embryo as a whole. Rather, by removing polar bodies/blastomeres, recent developments on preimplantation genetic diagnosis for aneuploidy screening (PGD-AS) have paved the way to detect and possibly eliminate the majority of chromosomally abnormal embryos, thereby increasing the chance of a healthy pregnancy. This article summarizes the origin and impact of chromosomal abnormalities on human reproduction in cases with repeated implantation failure (RIF) and unexplained recurrent miscarriage. It also discusses recent advances regarding the possible benefits of PGD-AS in such cases.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Embryo Implantation
/
Abortion, Habitual
/
Aneuploidy
Type of study:
Diagnostic_studies
/
Prognostic_studies
/
Screening_studies
Limits:
Adult
/
Female
/
Humans
/
Pregnancy
Language:
En
Journal:
Reprod Biomed Online
Journal subject:
MEDICINA REPRODUTIVA
Year:
2006
Document type:
Article
Affiliation country:
Turquía