Niacin skin flushing in schizophrenic and depressed patients and healthy controls.
Psychiatry Res
; 143(2-3): 303-6, 2006 Aug 30.
Article
in En
| MEDLINE
| ID: mdl-16837062
ABSTRACT
This study compares the skin reactions to the niacin flushing test of 16 schizophrenic patients with those of 17 depressed patients and 16 healthy controls. Methyl nicotinate (niacin) in a concentration of 0.1 M was applied to the forearm for 5 min. Significant differences could be observed between the group of schizophrenic patients (less flushing) in comparison to the other groups. There were no statistical differences in niacin flushing between patients with depression and healthy controls. Gender, age and the use of antipsychotic agents did not appear to be confounders. The differences in flushing within the group of schizophrenic patients were striking, however. Most patients showed little or no flushing, but some patients reacted strongly. Although the three groups could be differentiated by the niacin flushing test, to develop a reliable clinical application of this test, further research is necessary.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Schizophrenia
/
Depressive Disorder
/
Flushing
/
Niacin
Type of study:
Diagnostic_studies
Limits:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Psychiatry Res
Year:
2006
Document type:
Article
Affiliation country:
Países Bajos
Publication country:
IE
/
IRELAND
/
IRLANDA