CYK-4/GAP provides a localized cue to initiate anteroposterior polarity upon fertilization.
Science
; 313(5791): 1298-301, 2006 Sep 01.
Article
in En
| MEDLINE
| ID: mdl-16873611
ABSTRACT
The Caenorhabditis elegans anteroposterior axis is established in response to fertilization by sperm. Here we present evidence that RhoA, the guanine nucleotide-exchange factor ECT-2, and the Rho guanosine triphosphatase-activating protein CYK-4 modulate myosin light-chain activity to create a gradient of actomyosin, which establishes the anterior domain. CYK-4 is enriched within sperm, and paternally donated CYK-4 is required for polarity. These data suggest that CYK-4 provides a molecular link between fertilization and polarity establishment in the one-cell embryo. Orthologs of CYK-4 are expressed in sperm of other species, which suggests that this cue may be evolutionarily conserved.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Cell Polarity
/
Caenorhabditis elegans
/
GTPase-Activating Proteins
/
Caenorhabditis elegans Proteins
/
Embryo, Nonmammalian
Limits:
Animals
Language:
En
Journal:
Science
Year:
2006
Document type:
Article
Affiliation country:
Estados Unidos