A novel orally active small molecule potently induces G1 arrest in primary myeloma cells and prevents tumor growth by specific inhibition of cyclin-dependent kinase 4/6.

Baughn, Linda B; Di Liberto, Maurizio; Wu, Kaida; Toogood, Peter L; Louie, Tracey; Gottschalk, Rachel; Niesvizky, Ruben; Cho, Hearn; Ely, Scott; Moore, Malcolm A S; Chen-Kiang, Selina

Baughn, Linda B; Di Liberto, Maurizio; Wu, Kaida; Toogood, Peter L; Louie, Tracey; Gottschalk, Rachel; Niesvizky, Ruben; Cho, Hearn; Ely, Scott; Moore, Malcolm A S; Chen-Kiang, Selina.

Affiliation

Baughn LB; Department of Pathology, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA.

Cancer Res ; 66(15): 7661-7, 2006 Aug 01.

Article in En | MEDLINE | ID: mdl-16885367

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Collection: 01-internacional Database: MEDLINE Main subject: Piperazines / Pyridines / Cyclin-Dependent Kinase 4 / Cyclin-Dependent Kinase 6 / Multiple Myeloma Limits: Animals / Humans Language: En Journal: Cancer Res Year: 2006 Document type: Article Affiliation country: Estados Unidos Country of publication: Estados Unidos

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