The effects of the dual 5alpha-reductase inhibitor dutasteride on localized prostate cancer--results from a 4-month pre-radical prostatectomy study.
Prostate
; 66(15): 1674-85, 2006 Nov 01.
Article
in En
| MEDLINE
| ID: mdl-16927304
ABSTRACT
BACKGROUND:
As dihydrotestosterone (DHT) is the most potent androgen in the prostate, inhibition of the 5alpha-reductase isoenzymes, which convert testosterone to DHT, could be an appropriate target for the treatment of prostate cancer.METHODS:
Eighty-one men with clinically localized prostate cancer received daily dutasteride 3.5 or 0.5 mg, or no therapy for 4 months before radical prostatectomy. Histopathological assessments were conducted on prostatectomy specimens.RESULTS:
Treatment with dutasteride was associated with reductions in serum and intraprostatic DHT of >or=90%, and a decrease in total prostate and tumor volumes. No effect of dutasteride was noted on Gleason grade. Histopathological effects on benign tissue were similar but less prominent than those seen with androgen ablation, whereas there was no significant difference in cancer histology among the groups.CONCLUSIONS:
Dutasteride treatment results in similar but less marked changes compared with androgen ablation.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Prostatic Neoplasms
/
Azasteroids
/
Adenocarcinoma
/
Enzyme Inhibitors
/
5-alpha Reductase Inhibitors
Type of study:
Clinical_trials
Limits:
Aged
/
Aged80
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Prostate
Year:
2006
Document type:
Article
Affiliation country:
Canadá