Memory guided saccades in mesial temporal lobe epilepsy with hippocampal sclerosis.
Clin Neurophysiol
; 117(11): 2392-8, 2006 Nov.
Article
in En
| MEDLINE
| ID: mdl-16978920
ABSTRACT
OBJECTIVE:
Mesial temporal lobe epilepsy with hippocampal sclerosis (MTLE-HS) may involve extrahippocampal areas of structural and functional damage. The incidence and the features of this damage are still a matter of debate and vary depending on the method applied. Memory guided saccades (MGSs) with a memorization delay longer than 20s can be used reliably to evaluate the parahippocampal cortex.METHODS:
MGSs with 3 and 30s memorization delays were recorded with the search coil technique in six patients affected by right MTLE-HS, and in 13 healthy controls.RESULTS:
The patients were not able to reduce the MGSs residual amplitude error after the first saccade with a 30s memorization delay. This finding was more evident with leftward saccades.CONCLUSIONS:
MGS abnormalities suggested the functional involvement of the right parahippocampal cortex in most of the patients with MTLE-HS, and this supports the clinical and anatomopathological heterogeneity of the disease.SIGNIFICANCE:
MGSs can be used in patients with right MTLE-HS to detect a possible functional involvement of the ipsilateral parahippocampal cortex.
Search on Google
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Saccades
/
Epilepsy, Temporal Lobe
/
Hippocampus
/
Memory
Limits:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Clin Neurophysiol
Journal subject:
NEUROLOGIA
/
PSICOFISIOLOGIA
Year:
2006
Document type:
Article
Affiliation country:
Italia