Discovery of novel, highly potent and selective beta-hairpin mimetic CXCR4 inhibitors with excellent anti-HIV activity and pharmacokinetic profiles.

DeMarco, Steven J; Henze, Heiko; Lederer, Alexander; Moehle, Kerstin; Mukherjee, Reshmi; Romagnoli, Barbara; Robinson, John A; Brianza, Federico; Gombert, Frank O; Lociuro, Sergio; Ludin, Christian; Vrijbloed, Jan Willem; Zumbrunn, Jürg; Obrecht, Jean-Pierre; Obrecht, Daniel; Brondani, Vincent; Hamy, François; Klimkait, Thomas

DeMarco, Steven J; Henze, Heiko; Lederer, Alexander; Moehle, Kerstin; Mukherjee, Reshmi; Romagnoli, Barbara; Robinson, John A; Brianza, Federico; Gombert, Frank O; Lociuro, Sergio; Ludin, Christian; Vrijbloed, Jan Willem; Zumbrunn, Jürg; Obrecht, Jean-Pierre; Obrecht, Daniel; Brondani, Vincent; Hamy, François; Klimkait, Thomas.

Affiliation

DeMarco SJ; Chemistry Department, University of Zürich, Winterthurerstrasse 190, 8057 Zürich, Switzerland.

Bioorg Med Chem ; 14(24): 8396-404, 2006 Dec 15.

Article in En | MEDLINE | ID: mdl-17010618

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Collection: 01-internacional Database: MEDLINE Main subject: Oligopeptides / Peptides, Cyclic / HIV-1 / Molecular Mimicry / Anti-HIV Agents / Receptors, CXCR4 / Antimicrobial Cationic Peptides Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Bioorg Med Chem Journal subject: BIOQUIMICA / QUIMICA Year: 2006 Document type: Article Affiliation country: Suiza Country of publication: Reino Unido

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