Stripping voltammetric quantification of the anti-diabetic drug glipizide in bulk form and pharmaceutical formulation.
J Pharm Biomed Anal
; 43(4): 1465-9, 2007 Mar 12.
Article
in En
| MEDLINE
| ID: mdl-17045771
ABSTRACT
The electrochemical behavior of glipizide at the hanging mercury drop electrode (HMDE) was studied in B-R universal buffers of pH 1.7-11. The voltammograms exhibited a well-defined 4-electron irreversible cathodic peak which attributed to reduction of the two C=N of the pyrazine ring of glipizide molecule. Glipizide was found to has an interfacial adsorptive character onto the mercury electrode surface. A monolayer surface coverage of 1.02x10(-10)mol cm(-2) was estimated and hence each adsorbed glipizide molecule occupied an area of 1.63 nm(2) onto the mercury electrode surface. A simple and precise square-wave adsorptive cathodic stripping (SWAdCS) voltammetric procedure was described for quantification of bulk glipizide with a limit of detection of 1.5x10(-10)M and a limit of quantitation of 5x10(-10)M. The proposed procedure was successfully applied for quantitation of glipizide in its pharmaceutical formulation (Minidiab tablets) without interference from excipients.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Glipizide
/
Hypoglycemic Agents
Type of study:
Diagnostic_studies
Limits:
Humans
Language:
En
Journal:
J Pharm Biomed Anal
Year:
2007
Document type:
Article
Affiliation country:
Egipto