Humoral and cellular responses to influenza vaccination in human recipients naturally tolerant to a kidney allograft.
Am J Transplant
; 6(11): 2796-801, 2006 Nov.
Article
in En
| MEDLINE
| ID: mdl-17049065
Rare kidney allograft recipients enjoy unaltered graft function years after interruption of their immunosuppressive treatment. To assess the extent to which this state of 'operational tolerance' (TOL) is specific to the graft and not the result of a global immunodeficiency, we analyzed the response of such patients following influenza vaccination. Hemagglutination inhibition titers and frequency of IFNgamma-secreting T cells were measured before 1 and 3 months after vaccination. The proportion of healthy volunteers (HV) responding to vaccine was significantly higher than that of immunosuppressed (IS) patients. Three 'TOL' patients presented a humoral response similar to that of HV, whereas the two others had a poor response, like the IS recipients. Although the small number of patients does not allow for definitive conclusions to be made, these data suggest that the status of tolerance may be heterogeneous, with some patients with a global immunodeficiency and others with an adapted response to vaccination.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Influenza Vaccines
/
B-Lymphocytes
/
T-Lymphocytes
/
Kidney Transplantation
/
Immune Tolerance
Limits:
Humans
Language:
En
Journal:
Am J Transplant
Journal subject:
TRANSPLANTE
Year:
2006
Document type:
Article
Affiliation country:
Francia
Country of publication:
Estados Unidos