Antinociceptive activity of the pyranocoumarin seselin in mice.
Fitoterapia
; 77(7-8): 574-8, 2006 Dec.
Article
in En
| MEDLINE
| ID: mdl-17055189
ABSTRACT
Seselin an angular pyranocoumarin at dose of 0.5, 4.5 or 40.5 mg/kg inhibited the writhing response induced by acetic acid in a significant and dose-dependent manner, by 19.5%, 26.2% and 41.4%, respectively. Using the same doses, seselin elicited a significant inhibition of formalin response during the second phase (inflammatory), by 90.3%, 97.8% and 95.3%, respectively. Besides, a significant reduction of licking time was observed during the first phase (neurogenic) at the highest doses of seselin, by 34.4% and 66.9%, respectively. On the contrary, in the hot plate test no effect was observed after seselin treatment. In conclusion, seselin was able to inhibit inflammatory hyperalgesia, suggesting that this natural product possesses both important peripheral anti-inflammatory and antinociceptive properties.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Pain
/
Pyrans
/
Plant Extracts
/
Coumarins
/
Rutaceae
/
Analgesics
/
Phytotherapy
Limits:
Animals
Language:
En
Journal:
Fitoterapia
Year:
2006
Document type:
Article
Affiliation country:
Brasil