Dietary whey protein hydrolysate suppresses development of atopic dermatitis-like skin lesions induced by mite antigen in NC/Nga mice.
Allergol Int
; 55(2): 185-9, 2006 Jun.
Article
in En
| MEDLINE
| ID: mdl-17075256
ABSTRACT
BACKGROUND:
Oral administration of enzymatic hydrolysate of cow's milk whey protein (WPH) has been reported to produce an anti-inflammatory effect. Since inflammation plays a role in dermatitis of allergic disease, we examined the influence of WPH on the development of atopic dermatitis (AD)-like skin lesions, induced in NC/Nga mice by the mite antigen Dermatophagoides pteronyssinus (Dp).METHODS:
AD-like skin lesions were induced on the pinnae and backs of NC/Nga mice by daily application of Dp for 4 weeks. Mice were fed cow's milk casein (control), WPH or casein protein hydrolysate (CPH) diets for 2 weeks prior to Dp application. Clinical skin conditions were evaluated periodically by a clinical severity score, total serum IgE and soluble E-selectin levels were measured by enzyme linked immunosorbent assay (ELISA).RESULTS:
WPH-fed mice showed significantly less AD-like skin lesions than those fed casein diets at 2 and 4 weeks after Dp application. In contrast, CPH-fed mice had manifestations in a similar manner as casein-fed mice did, and did not show an inhibitory effect. Serum soluble E-selectin levels, known as a marker of disease activity in AD patients, were significantly lower in the WPH diet group.CONCLUSIONS:
Our results suggest that in addition to its hypoallergenicity an anti-inflammatory function, dietary WPH might be useful for reducing the severity of AD-like skin lesions.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Protein Hydrolysates
/
Dermatophagoides pteronyssinus
/
Dermatitis, Atopic
/
Immunosuppressive Agents
/
Milk Proteins
/
Antigens
Limits:
Animals
Language:
En
Journal:
Allergol Int
Journal subject:
ALERGIA E IMUNOLOGIA
Year:
2006
Document type:
Article
Affiliation country:
Japón