Toll-like receptor 4 polymorphism is associated with coronary stenosis but not with the occurrence of acute or old myocardial infarctions.
Scand J Clin Lab Invest
; 66(8): 667-75, 2006.
Article
in En
| MEDLINE
| ID: mdl-17101559
ABSTRACT
OBJECTIVE:
Atherosclerosis is considered to be a chronic inflammatory disease. Toll-like receptor 4 (TLR-4), a key mediator in activating inflammatory cascade, has an A-to-G functional polymorphism that changes aspartic acid to glycine at position 299. TLR-4 is activated by, for example, lipopolysaccharides. The purpose of this study was to investigate the role of a common Asp299Gly polymorphism of the TLR-4 gene in atherosclerosis. MATERIAL ANDMETHODS:
The study comprised autopsy material from 657 men (the Helsinki Sudden Death Study; mean age 53, range 33-70 years).RESULTS:
Fewer G-allele carriers had 3-vessel coronary artery disease compared with AA homozygotes (OR 0.32; 95 % CI, 0.12-0.88, p = 0.027), and they also had a lower mean value for maximal coronary stenosis (p = 0.019). TLR-4 polymorphism was not significantly associated with the occurrence of acute or old myocardial infarction (MI).CONCLUSIONS:
The G allele of the TLR-4 gene, which is associated with a lower inflammation response, was associated with a lower risk of coronary stenosis but not with the occurrence of MI and hence is not a major factor in the development of coronary atherosclerosis.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Polymorphism, Genetic
/
Death, Sudden, Cardiac
/
Coronary Stenosis
/
Toll-Like Receptor 4
/
Myocardial Infarction
Type of study:
Risk_factors_studies
Limits:
Humans
/
Male
/
Middle aged
Country/Region as subject:
Europa
Language:
En
Journal:
Scand J Clin Lab Invest
Year:
2006
Document type:
Article
Affiliation country:
Finlandia