The biological significance of mtNOS modulation.
Front Biosci
; 12: 1041-8, 2007 Jan 01.
Article
in En
| MEDLINE
| ID: mdl-17127359
ABSTRACT
In the last years, nitric oxide synthases (NOS) have been localized in mitochondria. At this site, NO yield directly regulates the activity of cytochrome oxidase, O(2) uptake and the production of reactive oxygen species. Recent studies showed that translocated neuronal nitric oxide synthase (nNOS) is posttranslationally modified including phosphorylation at Ser 1412 (in mice) and myristoylation in an internal residue. Different studies confirm that modified nNOS alpha is the main modulable isoform in mitochondria. Modulation of mtNOS was observed in different situations, like adaptation to reduced O(2) availability and hypoxia, adaptation to low environmental temperature, and processes linked to life and death by effects on kinases and transcription factors. We present here evidence about the role of mtNOS in the analyzed conditions.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Nitric Oxide Synthase Type I
/
Mitochondria
Limits:
Animals
Language:
En
Journal:
Front Biosci
Journal subject:
BIOLOGIA
Year:
2007
Document type:
Article
Affiliation country:
Argentina