Polymorphism at the glutathione S-transferase P1 locus in Korean patients with perennial allergic rhinitis.

ABSTRACT

BACKGROUND: Oxidative stresses, which induce the reactive oxygen species (ROS), can cause airway inflammation. The glutathione S-transferases (GSTs) protect cells against the effects of ROS. GSTP1 polymorphism may have some effect on allergic rhinitis. Therefore, we have compared the effects of GSTP1 polymorphisms on the perennial allergic rhinitis in Koreans. METHODS: Patients with perennial allergies (149 patients) were selected. The control group included 156 healthy people. Genotypes were evaluated via polymerase chain reaction and restriction fragment length polymorphism, using the Alw26I restriction enzyme. RESULTS: There was no significant difference between groups in the proportions of the Ile/Ile (wild type) and Ile/Val (heterozygote) genotypes. However, the Val/Val (mutant type homozygote) was expressed in only one case (0.7%) in the perennial allergic rhinitis group, as compared with 11 cases (7.1%) in the controls (p < 0.05). CONCLUSION: Our results indicate that the Val/Val genetic polymorphism of GSTP1 may exert some protective effects in allergic inflammation.