Pharmacological treatment of negative symptoms of schizophrenia: therapeutic opportunity or cul-de-sac?
Acta Psychiatr Scand
; 115(2): 93-100, 2007 Feb.
Article
in En
| MEDLINE
| ID: mdl-17244172
ABSTRACT
UNLABELLED Negative symptoms of schizophrenia are debilitating and they contribute to poor outcome in schizophrenia. Initial enthusiasm that second-generation antipsychotics would prove to be powerful agents to improve negative symptoms has given way to relative pessimism that the effects of current pharmacological treatments are at best modest. METHOD:
A review of the current 'state-of-play' of pharmacological treatments for negative symptoms in schizophrenia.RESULTS:
Treatment results to date have been largely disappointing. The evidence for efficacy of second-generation antipsychotics is reviewed.CONCLUSION:
The measurement and treatment trials methodology for the evaluation of negative symptoms need additional refinement before therapeutic optimism that better treatments for negative symptoms can be realized.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Schizophrenia
/
Schizophrenic Psychology
/
Antipsychotic Agents
Type of study:
Diagnostic_studies
Limits:
Humans
Language:
En
Journal:
Acta Psychiatr Scand
Year:
2007
Document type:
Article
Affiliation country:
Estados Unidos