Effect of human alpha-fetoprotein on native and in vitro-stimulated NK activity.
J Clin Lab Immunol
; 34(4): 183-8, 1991 Apr.
Article
in En
| MEDLINE
| ID: mdl-1726567
ABSTRACT
We have examined the effect of human alpha-fetoprotein (h-alpha FP), at concentrations ranging from the physiological to pathological circulating levels, on the native and alpha IFN- and IL2-boosted NK activity of normal peripheral blood lymphocytes (PBL). The cytotoxic function of unstimulated PBL was unchanged after a 16 hr incubation with 200 to 8000 ng/ml h-alpha FP. By contrast, this treatment significantly reduced the responsiveness of PBL to the NK-enhancer factors IFN and Interleukin 2. Optimal inhibition was observed when cells were pre-incubated with h-alpha FP before being stimulated with IFN. The sensitivity of PBL to the h-alpha FP mediated inhibition was restricted to the very early times (30 min) of incubation with the stimulating agents.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Killer Cells, Natural
/
Alpha-Fetoproteins
Limits:
Humans
Language:
En
Journal:
J Clin Lab Immunol
Year:
1991
Document type:
Article
Affiliation country:
Argentina