Increased hippocampal atrophy rates in AD over 6 months using serial MR imaging.
Neurobiol Aging
; 29(8): 1199-203, 2008 Aug.
Article
in En
| MEDLINE
| ID: mdl-17368654
ABSTRACT
We measured hippocampi on baseline-, 6- and 12-month scans in a group of AD (n=36) and control subjects (n=20). We found that mean annualised atrophy rates using 6-month intervals were comparable at a group level to those generated from a 12-month interval. Higher variance was seen using shorter intervals, although this was only significant in the control group. This has implications where shorter inter-scan intervals may be advantageous, such as rapid diagnosis, and tracking of disease progression including in a clinical trial.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Brain
/
Aging
/
Magnetic Resonance Imaging
/
Alzheimer Disease
/
Hippocampus
Type of study:
Clinical_trials
/
Observational_studies
Limits:
Aged
/
Female
/
Humans
/
Male
Language:
En
Journal:
Neurobiol Aging
Year:
2008
Document type:
Article
Affiliation country:
Reino Unido