LC-MS characterization of efficacy substances in serum of experimental animals treated with Sophora flavescens extracts.
Biomed Chromatogr
; 21(6): 655-60, 2007 Jun.
Article
in En
| MEDLINE
| ID: mdl-17370298
ABSTRACT
Anti-DHBV (duck hepatitis B virus) activity was found in the aqueous extracts of Sophora flavescens Ait. in vivo. Liquid chromatography/electrospray ionization ion trap mass spectrometry was applied to characterize the components in duck serum after oral administration of S. flavescens extract. Oxymatrine (1), sophoranol (2), sophoridine (3) and matrine (4) were identified in the serum. Further research on the four compounds was evaluated for their antiviral activity against HBV (hepatitis B virus) in cell culture. The results suggested that oxymatrine, sophoranol and matrine were the efficacy substances for anti-HBV activity in aqueous extracts of S. flavescens Ait.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Antiviral Agents
/
Virus Replication
/
Plant Extracts
/
Hepatitis B Virus, Duck
/
Chromatography, High Pressure Liquid
/
Hepadnaviridae Infections
/
Spectrometry, Mass, Electrospray Ionization
Limits:
Animals
Language:
En
Journal:
Biomed Chromatogr
Year:
2007
Document type:
Article
Publication country:
ENGLAND
/
ESCOCIA
/
GB
/
GREAT BRITAIN
/
INGLATERRA
/
REINO UNIDO
/
SCOTLAND
/
UK
/
UNITED KINGDOM