The type 1 equilibrative nucleoside transporter regulates anxiety-like behavior in mice.
Genes Brain Behav
; 6(8): 776-83, 2007 Nov.
Article
in En
| MEDLINE
| ID: mdl-17376149
ABSTRACT
Activation of adenosine receptors in the brain reduces anxiety-like behavior in animals and humans. Because nucleoside transporters regulate adenosine levels, we used mice lacking the type 1 equilibrative nucleoside transporter (ENT1) to investigate whether ENT1 contributes to anxiety-like behavior. The ENT1 null mice spent more time in the center of an open field compared with wild-type littermates. In the elevated plus maze, ENT1 null mice entered more frequently into and spent more time exploring the open arms. The ENT1 null mice also spent more time exploring the light side of a light-dark box compared with wild-type mice. Microinjection of an ENT1-specific antagonist, nitrobenzylthioinosine (nitrobenzylmercaptopurine riboside), into the amygdala of C57BL/6J mice reduced anxiety-like behavior in the open field and elevated plus maze. These findings show that amygdala ENT1 modulates anxiety-like behavior. The ENT1 may be a drug target for the treatment of anxiety disorders.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Anxiety
/
Equilibrative Nucleoside Transporter 1
/
Exploratory Behavior
/
Amygdala
/
Motor Activity
Limits:
Animals
Language:
En
Journal:
Genes Brain Behav
Journal subject:
CIENCIAS DO COMPORTAMENTO
/
GENETICA
Year:
2007
Document type:
Article
Affiliation country:
Estados Unidos