Allelic polymorphism in the Plasmodium vivax dihydrofolate reductase gene among Indian field isolates.
Clin Microbiol Infect
; 13(3): 331-4, 2007 Mar.
Article
in En
| MEDLINE
| ID: mdl-17391393
ABSTRACT
In total, 129 Plasmodium vivax isolates from different geographical areas in India were analysed for point mutations in the P. vivax dihydrofolate reductase gene that were associated with pyrimethamine resistance. A gradual increase in the frequency of mutant genotypes was observed from north to south (p <0.0001). In the northern region (Delhi, Panna and Nadiad), the wild-type genotype was most prevalent, while the mutant genotype predominated in the coastal regions of southern India (Navi Mumbai, Goa and Chennai). Isolates from the Car-Nicobar islands showed only mutant genotypes. The differential geographical pattern of mutations may be associated with the transmission pattern.
Search on Google
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Plasmodium vivax
/
Polymorphism, Genetic
/
Tetrahydrofolate Dehydrogenase
Limits:
Animals
Language:
En
Journal:
Clin Microbiol Infect
Journal subject:
DOENCAS TRANSMISSIVEIS
/
MICROBIOLOGIA
Year:
2007
Document type:
Article
Affiliation country:
India