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The L80I substitution in the reverse transcriptase domain of the hepatitis B virus polymerase is associated with lamivudine resistance and enhanced viral replication in vitro.
Warner, Nadia; Locarnini, Stephen; Kuiper, Michael; Bartholomeusz, Angeline; Ayres, Anna; Yuen, Lilly; Shaw, Tim.
Affiliation
  • Warner N; Victorian Infectious Diseases Reference Laboratory, North Melbourne, Victoria, Australia.
Antimicrob Agents Chemother ; 51(7): 2285-92, 2007 Jul.
Article in En | MEDLINE | ID: mdl-17438047
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Virus Replication / Hepatitis B virus / Reverse Transcriptase Inhibitors / Lamivudine / Drug Resistance, Viral / DNA-Directed DNA Polymerase Type of study: Risk_factors_studies Limits: Humans Language: En Journal: Antimicrob Agents Chemother Year: 2007 Document type: Article Affiliation country: Australia
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Virus Replication / Hepatitis B virus / Reverse Transcriptase Inhibitors / Lamivudine / Drug Resistance, Viral / DNA-Directed DNA Polymerase Type of study: Risk_factors_studies Limits: Humans Language: En Journal: Antimicrob Agents Chemother Year: 2007 Document type: Article Affiliation country: Australia