Discovery of a potent CDK2 inhibitor with a novel binding mode, using virtual screening and initial, structure-guided lead scoping.

Richardson, Christine M; Nunns, Claire L; Williamson, Douglas S; Parratt, Martin J; Dokurno, Pawel; Howes, Rob; Borgognoni, Jenifer; Drysdale, Martin J; Finch, Harry; Hubbard, Roderick E; Jackson, Philip S; Kierstan, Peter; Lentzen, Georg; Moore, Jonathan D; Murray, James B; Simmonite, Heather; Surgenor, Allan E; Torrance, Christopher J

Richardson, Christine M; Nunns, Claire L; Williamson, Douglas S; Parratt, Martin J; Dokurno, Pawel; Howes, Rob; Borgognoni, Jenifer; Drysdale, Martin J; Finch, Harry; Hubbard, Roderick E; Jackson, Philip S; Kierstan, Peter; Lentzen, Georg; Moore, Jonathan D; Murray, James B; Simmonite, Heather; Surgenor, Allan E; Torrance, Christopher J.

Affiliation

Richardson CM; Vernalis (R&D) Ltd, Granta Park, Cambridge CB21 6GB, UK. c.richardson@vernalis.com

Bioorg Med Chem Lett ; 17(14): 3880-5, 2007 Jul 15.

Article in En | MEDLINE | ID: mdl-17570665

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Collection: 01-internacional Database: MEDLINE Main subject: Protein Kinase Inhibitors / Cyclin-Dependent Kinase 2 Type of study: Diagnostic_studies / Screening_studies Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2007 Document type: Article Affiliation country: Reino Unido Country of publication: Reino Unido

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