Telomere biology of trypanosomatids: beginning to answer some questions.
Trends Parasitol
; 23(8): 357-62, 2007 Aug.
Article
in En
| MEDLINE
| ID: mdl-17580124
ABSTRACT
Studies of telomere structure and maintenance in trypanosomatids have provided insights into the evolutionary origin and conservation of some telomeric components shared by trypanosomes and vertebrates. For example, trypanosomatid telomeres are maintained by telomerase and consist of the canonical TTAGGG repeats, which in Trypanosoma brucei can form telomeric loops (t-loops). However, the telomeric chromatin of trypanosomatids is composed of organism-specific proteins and other proteins that share little sequence similarity with their vertebrate counterparts. Because telomere maintenance mechanisms are essential for genome stability, we propose that the particular features shown by the trypanosome telomeric chromatin hold the key for the design of antiparasitic drugs.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
DNA, Protozoan
/
Telomere
/
Trypanosomatina
/
Evolution, Molecular
Limits:
Animals
Language:
En
Journal:
Trends Parasitol
Journal subject:
PARASITOLOGIA
Year:
2007
Document type:
Article
Affiliation country:
Brasil