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Aberrant transcriptional regulatory network in T cells of multiple sclerosis.
Satoh, Jun-ichi; Illes, Zsolt; Peterfalvi, Agnes; Tabunoki, Hiroko; Rozsa, Csilla; Yamamura, Takashi.
Affiliation
  • Satoh J; Department of Bioinformatics, Meiji Pharmaceutical University, Tokyo, Japan. satoj@my-pharm.ac.jp
Neurosci Lett ; 422(1): 30-3, 2007 Jul 05.
Article in En | MEDLINE | ID: mdl-17629622
ABSTRACT
To identify the molecular network of the genes deregulated in multiple sclerosis (MS), we studied gene expression profile of purified CD3(+) T cells isolated from Hungarian monozygotic MS twins by DNA microarray analysis. By comparing three concordant and one discordant pairs, we identified 20 differentially expressed genes (DEG) between the MS patient and the genetically identical healthy subject. Molecular network of 20 DEG analyzed by KeyMolnet, a comprehensive information platform, indicated the close relationship with transcriptional regulation by the Ets transcription factor family and the nuclear factor NF-kappaB. This novel bioinformatic approach proposes the logical hypothesis that aberrant regulation of the complex transcriptional regulatory network contributes to development of pathogenic T cells in MS.
Subject(s)
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Collection: 01-internacional Database: MEDLINE Main subject: T-Lymphocytes / Gene Expression Regulation / Gene Regulatory Networks / Multiple Sclerosis Type of study: Prognostic_studies Limits: Adolescent / Child / Child, preschool / Female / Humans / Male Country/Region as subject: Europa Language: En Journal: Neurosci Lett Year: 2007 Document type: Article Affiliation country: Japón
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Collection: 01-internacional Database: MEDLINE Main subject: T-Lymphocytes / Gene Expression Regulation / Gene Regulatory Networks / Multiple Sclerosis Type of study: Prognostic_studies Limits: Adolescent / Child / Child, preschool / Female / Humans / Male Country/Region as subject: Europa Language: En Journal: Neurosci Lett Year: 2007 Document type: Article Affiliation country: Japón