Expression of nm23, MMP-2, TIMP-2 in breast neoplasm in Zhengzhou Center Hospital, China.
Ethiop Med J
; 45(1): 79-83, 2007 Jan.
Article
in En
| MEDLINE
| ID: mdl-17642161
ABSTRACT
BACKGROUND:
In recent years, the carcinoma of the breast threatens to women's health heavily. Invasion and metastasis is the main reason that results in the patients death.OBJECTIVE:
A prospective study is made in the center hospital of zhengzhou, in order to approach the expression of nm23, MMP-2 (Matrix metallo-proteinase-2), TIMP-2 (it's tissue-inhibitor of the metalloproteinase-2) in the breast neoplasm and the relationship with invasion and metastasis.METHODOLOGY:
This study applied the immunohistochemistry technique SP methodRESULTS:
In fibroadenoma, ductal carcinoma in situ and invasive ductal carcinoma of the breast 4 groups, the positive immunostaining rate of nm23, MMP-2 and TIMP-2 have significant difference among 4 groups (p < 0.05). In the breast invasive ductal carcinoma, the expression of nm23 and TIMP-2 decreased or the expression of MMP-2 increasedCONCLUSION:
This suggested that invasion and metastasis is ability of the neoplasm. MMP-2 in the breast ductal carcinoma in situ appears of high expression and this suggested that the positive expression of this onco-proteins was the early incident in the genetic course of the breast cancer The unite detection of nm23, MMP-2 and TIMP-2 expression would contribute to the early diagnosis and prognostic assessment of the carcinoma of the breast.
Search on Google
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Breast Neoplasms
/
Carcinoma in Situ
/
Fibroadenoma
/
Carcinoma, Ductal, Breast
/
Nucleoside-Diphosphate Kinase
/
Carcinoma, Ductal
/
Matrix Metalloproteinases, Membrane-Associated
/
Antineoplastic Agents
Type of study:
Observational_studies
/
Risk_factors_studies
/
Screening_studies
Limits:
Female
/
Humans
Country/Region as subject:
Asia
Language:
En
Journal:
Ethiop Med J
Year:
2007
Document type:
Article
Affiliation country:
China