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A distal methyl substituent attenuates mitochondrial protein synthesis inhibition in oxazolidinone antibacterials.
Renslo, Adam R; Atuegbu, Andy; Herradura, Prudencio; Jaishankar, Priyadarshini; Ji, Mingzhe; Leach, Karen L; Huband, Michael D; Dermyer, Michael R; Wu, Luping; Vara Prasad, J V N; Gordeev, Mikhail F.
Affiliation
  • Renslo AR; Pfizer Global Research and Development, 34790 Ardentech Ct., Fremont, CA 94555, USA. adam.renslo@ucsf.edu
Bioorg Med Chem Lett ; 17(18): 5036-40, 2007 Sep 15.
Article in En | MEDLINE | ID: mdl-17681758
ABSTRACT
Oxazolidinone analogs bearing substituted piperidine or azetidine C-rings are described. Analogs with a methyl group at the 3-position of the azetidine ring or the 4-position of the piperidine ring exhibited reduced mitochondrial protein synthesis inhibition while retaining good antibacterial potency.
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Collection: 01-internacional Database: MEDLINE Main subject: Protein Biosynthesis / Protein Synthesis Inhibitors / Oxazolidinones / Anti-Bacterial Agents / Mitochondria Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2007 Document type: Article Affiliation country: Estados Unidos
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Collection: 01-internacional Database: MEDLINE Main subject: Protein Biosynthesis / Protein Synthesis Inhibitors / Oxazolidinones / Anti-Bacterial Agents / Mitochondria Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2007 Document type: Article Affiliation country: Estados Unidos