A distal methyl substituent attenuates mitochondrial protein synthesis inhibition in oxazolidinone antibacterials.
Bioorg Med Chem Lett
; 17(18): 5036-40, 2007 Sep 15.
Article
in En
| MEDLINE
| ID: mdl-17681758
ABSTRACT
Oxazolidinone analogs bearing substituted piperidine or azetidine C-rings are described. Analogs with a methyl group at the 3-position of the azetidine ring or the 4-position of the piperidine ring exhibited reduced mitochondrial protein synthesis inhibition while retaining good antibacterial potency.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Protein Biosynthesis
/
Protein Synthesis Inhibitors
/
Oxazolidinones
/
Anti-Bacterial Agents
/
Mitochondria
Language:
En
Journal:
Bioorg Med Chem Lett
Journal subject:
BIOQUIMICA
/
QUIMICA
Year:
2007
Document type:
Article
Affiliation country:
Estados Unidos