Potent oxindole based human beta3 adrenergic receptor agonists.

Stevens, F Craig; Bloomquist, William E; Borel, Anthony G; Cohen, Marlene L; Droste, Christine A; Heiman, Mark L; Kriauciunas, Aidas; Sall, Daniel J; Tinsley, Frank C; Jesudason, Cynthia D

Stevens, F Craig; Bloomquist, William E; Borel, Anthony G; Cohen, Marlene L; Droste, Christine A; Heiman, Mark L; Kriauciunas, Aidas; Sall, Daniel J; Tinsley, Frank C; Jesudason, Cynthia D.

Affiliation

Stevens FC; Lilly Research Laboratories, Eli Lilly & Company, Lilly Corporate Center, Indianapolis, IN 46285, USA.

Bioorg Med Chem Lett ; 17(22): 6270-3, 2007 Nov 15.

Article in En | MEDLINE | ID: mdl-17911024

ABSTRACT

ABSTRACT

The synthesis and biological evaluation of a series of oxindole beta(3) adrenergic receptor agonists is described. A modulation of rat atrial tachycardia was observed with substitution at the 3-position of the oxindole moiety.

Subject(s)

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Collection: 01-internacional Database: MEDLINE Main subject: Tachycardia / Adrenergic beta-Agonists / Adrenergic beta-3 Receptor Agonists / Indoles Limits: Animals / Humans Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2007 Document type: Article Affiliation country: Estados Unidos

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