Treatment of children persistently infected with hepatitis B virus: seroconversion or suppression.
J Antimicrob Chemother
; 60(6): 1189-92, 2007 Dec.
Article
in En
| MEDLINE
| ID: mdl-17913721
ABSTRACT
We have reviewed the current strategies regarding the treatment of persistent hepatitis B virus (HBV) in children and compared these with adult strategies. The options for achieving suppression of viral DNA replication versus hepatitis B e antigen to antibody seroconversion have been evaluated. The results of studies in different geographical locations have been confounded by HBV genotypes, as it is now clear that some genotypes respond better to treatment than others. Consideration needs to be given as to whether optimal treatment strategies developed for adults are directly applicable to children. In children, early seroconversion to allow improved long-term outcomes should be considered rather than embarking on the long-term complexities of managing patients on a combination of antiviral drugs to achieve viral suppression.
Search on Google
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Antiviral Agents
/
Hepatitis B virus
/
Interferon-alpha
/
Lamivudine
/
Hepatitis B, Chronic
Limits:
Child
/
Child, preschool
/
Humans
/
Infant
Language:
En
Journal:
J Antimicrob Chemother
Year:
2007
Document type:
Article
Affiliation country:
Reino Unido